Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli-Responsive, Toxicity, Immunogenicity, and Clinical Translation Publisher



Sharifi E1, 2 ; Bigham A2 ; Yousefiasl S3 ; Trovato M4 ; Ghomi M5, 6 ; Esmaeili Y7 ; Samadi P8 ; Zarrabi A9, 10 ; Ashrafizadeh M11 ; Sharifi S12 ; Sartorius R4 ; Dabbagh Moghaddam F13 ; Maleki A14 ; Song H15 Show All Authors
Authors
  1. Sharifi E1, 2
  2. Bigham A2
  3. Yousefiasl S3
  4. Trovato M4
  5. Ghomi M5, 6
  6. Esmaeili Y7
  7. Samadi P8
  8. Zarrabi A9, 10
  9. Ashrafizadeh M11
  10. Sharifi S12
  11. Sartorius R4
  12. Dabbagh Moghaddam F13
  13. Maleki A14
  14. Song H15
  15. Agarwal T16
  16. Maiti TK16
  17. Nikfarjam N17
  18. Burvill C12
  19. Mattoli V18
  20. Raucci MG2
  21. Zheng K18
  22. Boccaccini AR19
  23. Ambrosio L2
  24. Makvandi P20

Source: Advanced Science Published:2022


Abstract

Cancer is one of the top life-threatening dangers to the human survival, accounting for over 10 million deaths per year. Bioactive glasses have developed dramatically since their discovery 50 years ago, with applications that include therapeutics as well as diagnostics. A new system within the bioactive glass family, mesoporous bioactive glasses (MBGs), has evolved into a multifunctional platform, thanks to MBGs easy-to-functionalize nature and tailorable textural properties—surface area, pore size, and pore volume. Although MBGs have yet to meet their potential in tumor treatment and imaging in practice, recently research has shed light on the distinguished MBGs capabilities as promising theranostic systems for cancer imaging and therapy. This review presents research progress in the field of MBG applications in cancer diagnosis and therapy, including synthesis of MBGs, mechanistic overview of MBGs application in tumor diagnosis and drug monitoring, applications of MBGs in cancer therapy (particularly, targeted delivery and stimuli-responsive nanoplatforms), and immunological profile of MBG-based nanodevices in reference to the development of novel cancer therapeutics. © 2021 The Authors. Advanced Science published by Wiley-VCH GmbH
Other Related Docs
4. Co-Delivery of Stat3 Sirna and Methotrexate in Breast Cancer Cells, Artificial Cells, Nanomedicine and Biotechnology (2022)
11. Mxenes in Cancer Nanotheranostics, Nanomaterials (2022)