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Covalent Triazine-Based Polyimine Framework As a Biocompatible Ph-Dependent Sustained-Release Nanocarrier for Sorafenib: An in Vitro Approach Publisher

Summary: Research shows a new carrier boosts sorafenib’s delivery to cancer cells, enhancing prostate cancer treatment. #CancerResearch #DrugDelivery

Mokhtari N1 ; Taymouri S2 ; Mirian M3 ; Dinari M1
Authors

Source: Journal of Molecular Liquids Published:2020


Abstract

In the present study, a novel polyimine-based covalent triazine framework (PI-CTF) was introduced as a promising biocompatible carrier for sorafenib (SFN) delivery. High specific surface area and porosity allowed us to achieve drug loading and encapsulation efficiency as high as 83% and 98%, respectively. The in vitro drug release study of SFN-loaded PI-CTF showed a sustained and pH-dependent release behavior in which acidic pH accelerated drug release compared with the neutral pH. Notably, cytotoxicity assay against L929 cells revealed the safety and biocompatibility of PI-CTF. Moreover, MTT assay against LNCaP prostate cancer cells expressed that the anticancer activity of SFN had no diminution after incorporating into PI-CTF. Thus, PI-CTF has envisaged as a great promise toward anti-cancer drug carrier. © 2019 Elsevier B.V.
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