Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Effects of Some Parameters on Particle Size Distribution of Chitosan Nanoparticles Prepared by Ionic Gelation Method Publisher



Vaezifar S1 ; Razavi S2 ; Golozar MA1 ; Karbasi S3 ; Morshed M4 ; Kamali M5
Authors

Source: Journal of Cluster Science Published:2013


Abstract

In this research, chitosan nanoparticles were prepared based on the ionic gelation of chitosan with tripolyphosphate anions. Effects of parameters such as chitosan concentration, tripolyphosphate concentration, and reaction time on the particle size distribution were investigated. In order to determine optimum conditions, tests were designed by Qualitek-4 software, using Taguchi method. The best conditions were determined based on three factors at three levels. Therefore, the main object was to investigate the effect of some parameters on particle size distribution and determine the optimum conditions for preparing chitosan nanoparticles by ionic gelation, followed by evaluation of the physicochemical and structural properties. The size distribution of original chitosan and chitosan nanoparticles were determined by Laser Diffraction and Dynamic Light Scattering, respectively. The physicochemical properties of the chitosan nanoparticles were studied using SEM, TEM, XRD pattern, FTIR, UV-vis, TGA, and NMR spectra. The optimum chitosan concentration, tripolyphosphate concentration, and reaction time were found to be 1.0 mg/ml, 1.0 mg/ml, and 60 min, respectively. © 2013 Springer Science+Business Media New York.
Related Docs
View other Related Docs
1. Sustained-Release of Erythropoietin Using a Novel Injectable Thermosensitive Hydrogel: In Vitro Studies, Biological Activity, and Efficacy in Rats, Pharmaceutical Development and Technology (2021)
2. Immobilization of Alkaline Phosphatase Using Chitosan Nanoparticles, Russian Journal of Applied Chemistry (2015)
3. Study on the Preparation and Properties of Polyamide/Chitosan Nanocomposite Fabricated by Electrospinning Method, Journal of Polymers and the Environment (2022)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (7)
Vajihe Akbari (3)
Other Related Docs
4. Stability Improvement of Immobilized Alkaline Phosphatase Using Chitosan Nanoparticles, Brazilian Journal of Chemical Engineering (2016)
5. Immobilization of Alkaline Phosphatase Using Chitosan Nanoparticles for Enhancing Its Stability, Russian Journal of Applied Chemistry (2014)
6. Effect of Polymer Molecular Weight on Morphology and Particle Size of Chitosan Microspheres Prepared Via Spray Drying Method, IFMBE Proceedings (2009)
7. Chitosan-Titanium Dioxide-Glucantime Nanoassemblies Effects on Promastigote and Amastigote of Leishmania Major, International Journal of Biological Macromolecules (2018)
8. Preparation and Characterization of Gelatin/Chitosan Nanocomposite Reinforced by Nio Nanoparticles As an Active Food Packaging, Scientific Reports (2024)
9. Fabrication, Characterization and Antimicrobial Activity of Chitosan/Tragacanth Gum/Polyvinyl Alcohol Composite Films Incorporated With Cinnamon Essential Oil Nanoemulsion, International Journal of Biological Macromolecules (2023)
10. Synthesis of Ph-Responsive Carboxymethyl Chitosan for Encapsulating Tetracycline-Hcl: Morphology, Drug Release Behavior and Antibacterial Activity of Microcapsules, Journal of Drug Delivery Science and Technology (2023)
11. Electrospun Ag-Decorated Reduced Go-Graft-Chitosan Composite Nanofibers With Visible Light Photocatalytic Activity for Antibacterial Performance, Chemosphere (2022)
12. Permeation Enhancer Effect of Chitosan and Chitosan Derivatives: Comparison of Formulations As Soluble Polymers and Nanoparticulate Systems on Insulin Absorption in Caco-2 Cells, European Journal of Pharmaceutics and Biopharmaceutics (2008)
13. Acceleration of Wound Healing in Rats by Modified Lignocellulose Based Sponge Containing Pentoxifylline Loaded Lecithin/Chitosan Nanoparticles, Gels (2022)
14. Evaluation of Phb-Chitosan/Cnc Scaffolds' Applicability for Bone Tissue Engineering Via Mg-63 Osteoblastic Cell Cultivation and Osteogenic Markers Gene Expression, International Journal of Biological Macromolecules (2025)
15. Physical, Mechanical and Biological Evaluation of Poly (3-Hydroxybutyrate)-Chitosan/Mwnts As a Novel Electrospun Scaffold for Cartilage Tissue Engineering Applications, Polymer-Plastics Technology and Materials (2020)
16. Preparation of Chitosan Nanoparticles for Simultaneous Drug Delivery of Dacarbazine and Enoxaparin in Melanoma, Carbohydrate Polymers (2023)
17. Preparation and in Vitro Characterization of Histidine Trimethyl Chitosan Conjugated Nanocomplex Incorporated Into Injectable Thermosensitive Hydrogels for Localized Gene Delivery, Biotechnology and Applied Biochemistry (2022)
18. Preparation, Physicochemical, and Retinal Anti-Angiogenic Evaluation of Poloxamer Hydrogel Containing Dexamethasone/Avastin-Loaded Chitosan-N-Acetyl-L-Cysteine Nanoparticles, International Journal of Biological Macromolecules (2022)
19. Synthesis and Characterization of Core-Shell Fe 3O 4-Gold-Chitosan Nanostructure, Journal of Nanobiotechnology (2012)
20. Preparation, Characterization and Optimization of Glipizide Controlled Release Nanoparticles, Research in Pharmaceutical Sciences (2014)