Cytotoxic Sulfoquinovosyl Glycerols From the Seaweed Sargassum Angustifolium From Persian Gulf Publisher

Summary: Seaweed-derived compounds show cytotoxic effects against cancer cells. This study reveals promising cytotoxicity of Sargassum angustifolium extracts, which may aid cancer treatment. Are marine organisms the next big thing in drug discovery? #CancerResearch #MarineBiology

Se Sajjadi Seyed EBRAHIM ; S Ghobeishavi SAHAR ; A Yekdaneh AFSANEH
Source: Advanced Biomedical Research Published:2025

Abstract

Backgrounds: Seaweeds are an important source of marine organisms that produce a lot of bioactive compounds. Materials and Methods: In this research, the seaweed Sargassum angustifolium was collected from Bushehr province of Persian Gulf of Iran. The seaweed was extracted by methanol:ethyl acetate (1:1) using maceration method. The compounds were isolated with different column chromatography and HPLC(High Performance Liquid Chromatography) by silica gel and hexane:ethyl acetate as mobile phase. Results: The isolated compounds were elucidated structurally by various 1 and 2 D-NMR and MS spectra. Besides the cytotoxicity test was done against HeLa using standard MTT assay and normal cells. Conclusion: It afforded four known sulfoquinovosyl diacylglycerides and fucosterol. Compounds 1-5 showed cytotoxic effects against HeLa and HUVEC cell lines, with IC50 values of 12.2 ± 2.3, 25.8 ± 3.7, 14.9 ± 2.6, 9.8 ± 1.2 μM, and 5.6 ± 1.2, respectively. © 2025 Elsevier B.V., All rights reserved.