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Protection of Renal Tubular Cells by Antioxidants: Current Knowledge and New Trends



Baradaran A1 ; Nasri H2 ; Rafieiankopaei M3
Authors

Source: Cell Journal Published:2015

Abstract

Acute renal damage mainly develops following toxic or ischemic insults and is defined as acute. These damages have largely been attributed to oxidative stress. Recently much attention has been directed toward decreased renal tubular cell regeneration during tubular cell injury. Antioxidants have recently been the focus of researchers and scientists for prevention and treatment of various oxidative stress-related conditions, including renal toxicities. Although free radicals are known to contribute in kidney injury and abundant researches, particularly laboratory trials, have shown the beneficial effects of antioxidants against these complications, long term clinical trials do not uniformly confirm this matter, especially for single antioxidant consumption such as vitamin C. The aim of this paper is to discuss the possible explanation of this matter.
1. Plants Antioxidants: From Laboratory to Clinic, Journal of Nephropathology (2013)
2. Kidney Tubular Cell Protection; Recent Findings, Iranian Journal of Pediatrics (2014)
3. Silybum Marianum: Beyond Hepatoprotection, Journal of Evidence-Based Complementary and Alternative Medicine (2015)
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