Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Cause-Specific Risk Factors of Death in Individuals With Diabetes: A Competing Risks Modeling Publisher

Summary: Research finds 75% of type 2 diabetes deaths are from heart disease or stroke, linked to hypertension and long diabetes duration. #Diabetes #HeartHealth

Mansourian M1 ; Sadeghpour S1 ; Aminorroaya A2 ; Amini M2 ; Jafarikoshki T3, 4
Authors

Source: International Journal of Endocrinology and Metabolism Published:2019


Abstract

Background: Diabetes is on the rise worldwide. Objectives: This study aimed to evaluate the risk factors of various causes of death in people with type 2 diabetes (T2D). Methods: In this cohort study on 2638 people with T2D, we applied cause-specific and sub-distribution hazards models to assess the impact of various factors on the risk of death. Moreover, we plotted a cumulative incidence curve to summarize cumulative failure rates over time. Results: About 75% of individuals with T2D died from cardiovascular disease (CVD) and cerebrovascular accidents (CVA). Death from CVD was associated with the increased risk of hypertension (hazard ratio (HR) = 1.83, 95% CI: 1.37 - 2.46), hypercholesterolemia (HR = 1.58, 95% CI: 1.17 - 2.14), and diabetes duration. The risk of death from CVA was related to hypertension (HR = 2.76, 95% CI: 1.67 - 4.55) and hyperglycemia (HR = 4.34, 95% CI: 1.75 - 10.79). The CVA risk in patients with diabetes duration of 10 - 20 years was higher than the risk in patients with diabetes duration > 20 years (diabetes duration of ≤ 10 years as the reference category). Diabetes duration of longer than 20 years was associated with a higher risk of death from cancer (HR = 2.65, 95% CI: 1.05 - 6.68). The risk of death from foot infection and diabetic nephropathy increased in patients with longer diabetes duration after adjustment for sex, age, and body mass index. Conclusions: Regardless of the cause, death rates in people with T2D increase over time and risk factors have different impacts on death from each cause. This should be acknowledged in risk management in individuals with T2D. Copyright © 2019, International Journal of Endocrinology and Metabolism.
Related Docs
View other Related Docs
1. Absolute Mortality Risk Assessment of Covid-19 Patients: The Khorshid Covid Cohort (Kcc) Study, BMC Medical Research Methodology (2021)
2. Association of the Triglyceride Glucose Index With All-Cause and Cardiovascular Mortality in a General Population of Iranian Adults, Cardiovascular Diabetology (2024)
3. Avoidable Burden of Cardiovascular Diseases in the Eastern Mediterranean Region: Contribution of Selected Risk Factors for Cardiovascular-Related Deaths, High Blood Pressure and Cardiovascular Prevention (2019)
Experts (# of related papers)
View all Related Experts
Nizal Sarrafzadegan (9)
Masoumeh Sadeghi (5)
Cause-Specific Risk Factors of Death in Individuals With Diabetes: A Competing Risks Modeling
Other Related Docs
4. Incidence and Predictors of Type 2 Diabetes Mellitus During 17 Years of Follow-Up in the Golestan Cohort Study, Scientific Reports (2025)
5. Cardiovascular Mortality in a Western Asian Country: Results From the Iran Cohort Consortium, BMJ Open (2018)
6. Contrasting Associations Between Diabetes and Cardiovascular Mortality Rates in Low-, Middle-, and High-Income Countries: Cohort Study Data From 143,567 Individuals in 21 Countries in the Pure Study, Diabetes Care (2020)
7. Association of Triglyceride Glucose Index With Cardiovascular Events: Insights From the Isfahan Cohort Study (Ics), European Journal of Medical Research (2024)
8. Diabetes and All-Cause Mortality, a 18-Year Follow-Up Study, Scientific reports (2020)
9. Pre-Hypertension, Pre-Diabetes or Both: Which Is Best at Predicting Cardiovascular Events in the Long Term?, Journal of Human Hypertension (2017)
10. Multistate Models to Predict Development of Late Complications of Type 2 Diabetes in an Open Cohort Study, Diabetes, Metabolic Syndrome and Obesity (2020)
11. Integration of Diabetes Mellitus and Hypertension on Major Cardiovascular Events: An Experience From a 15-Year Follow-Up Cohort Study in Emr, Current Diabetes Reviews (2024)
12. Association of Lipid Profile With Type 2 Diabetes in First-Degree Relatives: A 14-Year Follow-Up Study in Iran, Diabetes, Metabolic Syndrome and Obesity (2020)
13. Global, Regional, and National Burden of Diabetes From 1990 to 2021, With Projections of Prevalence to 2050: A Systematic Analysis for the Global Burden of Disease Study 2021, The Lancet (2023)
14. Developing Non-Laboratory Cardiovascular Risk Assessment Charts and Validating Laboratory and Non-Laboratory-Based Models, Global Heart (2021)
15. Modifiable Risk Factors, Cardiovascular Disease, and Mortality in 155 722 Individuals From 21 High-Income, Middle-Income, and Low-Income Countries (Pure): A Prospective Cohort Study, The Lancet (2020)
16. Incidence of Cardiovascular Events in Hypertensive Patients Based on the Quantity of Major Risk Factors According to the Isfahan Cohort Study, International Journal of Hypertension (2025)
17. Long-Term Exposure to Pm2.5 and Cardiovascular Disease Incidence and Mortality in an Eastern Mediterranean Country: Findings Based on a 15-Year Cohort Study, Environmental Health: A Global Access Science Source (2021)
18. Low-Density Lipoprotein Cholesterol and Risk of Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2018)
19. Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality, New England Journal of Medicine (2021)
20. Transition in Public Knowledge of Risk Factors of Cardiovascular Disease in an Iranian General Population: A Latent Transition Analysis (Lta) on a Longitudinal Large Community-Based Educational Prevention Program, ARYA Atherosclerosis (2016)