Nanobodies, the Potent Agents to Detect and Treat the Coronavirus Infections: A Systematic Review

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Nanobodies, the Potent Agents to Detect and Treat the Coronavirus Infections: A Systematic Review Publisher Pubmed

Zare H¹ ; Aghamollaei H² ; Hosseindokht M³ ; Heiat M⁴ ; Razei A⁵ ; Bakherad H⁶

Source: Molecular and Cellular Probes Published:2021

Abstract

The newly emerged coronavirus (SARS-CoV-2) continues to infect humans, and no effective treatment has yet been found. Antibody therapy is one way to control infection caused by COVID-19. However, the use of classical antibodies raises complex issues. Heavy chain antibodies (HCAbs) are single-domain antibodies derived from the Camelidae family. The variable part of these antibodies (Nanobodies or VHH) has interesting properties such as small size, cost-effective production, and good tissue permeability, causing VHH to be regarded as an antiviral therapeutics. However, the small size of nanobodies may lead to low antigen binding affinity and rapid renal clearance. In this systematic review, the application of nanobodies in the treatment of COVID-19 infection and other similar infections (MERS and SARS) was reviewed. © 2020

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Style	Citing Format
MLA	Zare H, et al.. "Nanobodies, the Potent Agents to Detect and Treat the Coronavirus Infections: A Systematic Review." Molecular and Cellular Probes, vol. 55, no. , 2021, pp. -.
APA	Zare H, Aghamollaei H, Hosseindokht M, Heiat M, Razei A, Bakherad H (2021). Nanobodies, the Potent Agents to Detect and Treat the Coronavirus Infections: A Systematic Review. Molecular and Cellular Probes, 55(), -.
Chicago	Zare H, Aghamollaei H, Hosseindokht M, Heiat M, Razei A, Bakherad H. "Nanobodies, the Potent Agents to Detect and Treat the Coronavirus Infections: A Systematic Review." Molecular and Cellular Probes 55, no. (2021): -.
Harvard	Zare H et al. (2021) 'Nanobodies, the Potent Agents to Detect and Treat the Coronavirus Infections: A Systematic Review', Molecular and Cellular Probes, 55(), pp. -.
Vancouver	Zare H, Aghamollaei H, Hosseindokht M, Heiat M, Razei A, Bakherad H. Nanobodies, the Potent Agents to Detect and Treat the Coronavirus Infections: A Systematic Review. Molecular and Cellular Probes. 2021;55():-.
BibTex	@article{ author = {Zare H and Aghamollaei H and Hosseindokht M and Heiat M and Razei A and Bakherad H}, title = {Nanobodies, the Potent Agents to Detect and Treat the Coronavirus Infections: A Systematic Review}, journal = {Molecular and Cellular Probes}, volume = {55}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Zare H AU - Aghamollaei H AU - Hosseindokht M AU - Heiat M AU - Razei A AU - Bakherad H TI - Nanobodies, the Potent Agents to Detect and Treat the Coronavirus Infections: A Systematic Review JO - Molecular and Cellular Probes VL - 55 IS - SP - EP - PY - 2021 ER -

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