Isfahan University of Medical Sciences

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Cytarabine and Doxorubicin-Induced Palmoplantar Erythrodysesthesia Syndrome: The Possible Role of Voriconazole Interaction Publisher



Tavakoliardakani M1 ; Haghighi S2 ; Shokouhi S3 ; Abtahinaeini B4 ; Meidani M5 ; Hassanpour R1 ; Saffaei A6
Authors

Source: Eurasian Journal of Medicine Published:2019


Abstract

Palmoplantar Erythrodysesthesia Syndrome (PPES) caused by chemotherapeutic agents is rarely life threatening and requires a reduction in dose or discontinuation of chemotherapy. The use of cytarabine and doxorubicin in the treatment of acute myeloid leukemia (AML) along with voriconazole can potentially alter the metabolism of the drugs and cause some interactions. In this study, we presented a case of AML who received cytarabine and doxorubicin as a chemotherapy regimen and voriconazole as a prophylactic anti-fungalIn this combination, voriconazole probably inhibits the P-glycoprotein pump, which leads to an increase in the cytarabine concentration. The emphasis of this report is the awareness of clinicians and pharmacotherapists about these interactions. © 2019, AVES. All rights reserved.