Isfahan University of Medical Sciences

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Incorporation of Zeolite and Silica Nanoparticles Into Electrospun Pva/Collagen Nanofibrous Scaffolds: The Influence on the Physical, Chemical Properties and Cell Behavior Publisher

Summary: Research shows scaffolds with zeolite and silica nanoparticles boost cartilage cell growth, promising better tissue engineering for joint repair. #TissueEngineering #MedicalResearch

Mehrasa M1 ; Anarkoli AO2 ; Rafienia M3 ; Ghasemi N2, 4 ; Davary N5 ; Bonakdar S6 ; Naeimi M7 ; Agheb M8 ; Salamat MR3, 9
Authors

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2016


Abstract

Cartilage is under extensive investigation in tissue engineering research. Herein, we evaluated scaffolds prepared by composites of polyvinyl alcohol (PVA) and collagen incorporated with zeolite and silica nanoparticles (nZe and nSi). The scaffolds were prepared by the electrospinning method. The mean diameters of nanofibers were 0.61 ± 0.34 μm for PVA/collagen versuss 0.62 ± 0.22 μm and 0.66 ± 0.25 μm for the PVA/collagen/nZe and the PVA/collagen/nSi scaffolds, respectively. DAPI staining results revealed that cell proliferations on the PVA/collagen/nZe and PVA/collagen/nSi were strikingly higher than on the pure PVA/collagen. The results encouraged further investigation of PVA/collagen/nSi scaffolds as biomimetic platform for chondrocyte cells in tissue engineering. © 2016 Taylor & Francis Group, LLC.
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