Effects of Pomegranate on Blood Pressure and Endothelial Function: A Systematic Review and Meta-Analysis of Clinical Trials Publisher



Sanei M ; Bonyadian A ; Maroofi M ; Nikrad N ; Noshadi N ; Darzi M ; Hadipour A ; Askari G ; Vajdi M
Source: Human Nutrition and Metabolism Published:2026

Abstract

This systematic review and meta-analysis evaluated pomegranate supplementation effects on blood pressure and endothelial function in adults. Four main databases, including PubMed/MEDLINE, Web of Science, SCOPUS, and Embase databases, were searched from inception to January 2026 to identify clinical trials. The pooled weighted/standardized mean differences (WMDs/SMDs) and 95% CIs were computed using the random-effects model. The Findings from 33 studies indicated significant reductions in systolic blood pressure (WMD: −3.52 mmHg; 95% CI: −4.97 to −2.06; P < 0.001), diastolic blood pressure (WMD: −1.50 mmHg; 95% CI: −2.58 to −0.42; P = 0.006), interleukin (IL)-6 (SMD: −0.82; 95% CI: −1.29 to −0.35; P = 0.001), and intercellular adhesion molecule 1 (ICAM-1) levels (SMD: −0.59; 95% CI: −0.97 to −0.22; P = 0.002). However, analysis indicated a nonsignificant effect on vascular cell adhesion protein 1 (VCAM-1), and E-selectin. In conclusion, it appears that pomegranate can lead to significant improvements in blood pressure, IL-6, and ICAM-1 levels. Future studies are needed to investigate the effect of pomegranate on blood pressure and endothelial function in adults. © 2026 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license. http://creativecommons.org/licenses/by/4.0/