A Chronic Autochthonous Fifth Clade Case of Candida Auris Otomycosis in Iran Publisher Pubmed

Summary: Study reports new Candida auris case in Iran’s fifth clade. Why is it spreading? #CandidaAuris #InfectiousDisease

Safari F¹ ; Madani M¹ ; Badali H^{2, 3} ; Kargoshaie AA⁴ ; Fakhim H⁵ ; Kheirollahi M⁶ ; Meis JF^{7, 8} ; Mirhendi H^{1, 9, 10}
Source: Mycopathologia Published:2022

Abstract

Candida auris, a multidrug-resistant nosocomial pathogen, has emerged globally with high morbidity and mortality among immunocompromised individuals and COVID19 hospitalized patients. Five major clades of C. auris have been previously described. The fifth clade is exclusively found in Iran where C. auris isolates are genetically distinct from other clades by > 200,000 single-nucleotide polymorphisms. The origin of C. auris remains unclear, and limited clinical data are available at present regarding clade V infection or colonization. Herein, another case of otomycosis in Iran caused by an isolate of C. auris belonging to the fifth clade is reported. Genotyping revealed that the obtained C. auris isolate from Isfahan clustered with earlier clade V isolates from Babol, cities around 600 km separated, which indicates that C. auris clade V is established in Iran. C. auris is thought to exist more commonly in Iran, given that limited diagnostic capacity in the country has probably curbed the identification of more C. auris cases. Therefore, surveillance of the environment, patients and healthcare facilities in different geographical regions in Iran is urgently required. © 2021, The Author(s), under exclusive licence to Springer Nature B.V.