Optic Neuritis Following Covid-19 Vaccination: Case Series and Review of the Literature; [Nevrite Optique Apres Vaccination Contre La Covid-19: Serie De Cas Et Revue De La Litterature] Publisher Pubmed



Etemadifar M¹ ; Nouri H^{2, 3, 4} ; Abtahi SH^{5, 6} ; Bathaei R^{2, 4} ; Mardi R⁴ ; Salari M⁷ ; Dehghani A⁸ ; Panahi Seifabad M^{4, 8} ; Jannesari A^{2, 4}
Source: Journal Francais d'Ophtalmologie Published:2024

Abstract

Objective: To review cases of optic neuritis after COVID-19 vaccination and add similar cases to the literature. Methods: Thorough PubMed and Scopus searches were conducted, and data from studies describing optic neuritis after COVID-19 vaccination were extracted, tabulated, pooled, and reviewed. Results: We present 6 cases of optic neuritis following COVID-19 vaccination. Our literature search yielded 48 similar cases. All 54 cases were divided into 3 groups with respect to their serostatus: (1) double-seronegative or unknown serostatus optic neuritis cases, (2) myelin oligodendrocyte glycoprotein (MOG)-associated optic neuritis cases, and (3) aquaporin-4-associated optic neuritis cases. Data from each group were separately pooled and reviewed. While the most frequent vaccine among the anti-AQP4+ subgroup was BNT162b2 (Pfizer-BioNTech) (2/3), recombinant vaccines, e.g., AZD122 and Ad26.Cov2.s were mostly injected in the other subgroups (23/51). No significant gender inclination was seen among different subgroups. The mean interval from vaccination to symptom onset was less than one month in all subgroups; symptom manifestations mainly occurred after the first dose (28/54). Almost all cases showed improvement after steroid therapy ± plasma exchange (52/54). Conclusion: Despite having rare side effects such as optic neuritis, vaccination remains our most helpful protection against SARS-CoV-2. Nevertheless, larger studies are needed to ascertain the pathophysiology of such adverse effects. Likewise, the association between COVID-19 vaccination and optic neuritis warrants further investigation. © 2024 Elsevier Masson SAS