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The Effect of Structural Changes on Swelling Kinetics of Polybasic/Hydrophobic Ph-Sensitive Hydrogels Publisher Pubmed



Falamarzian M1 ; Varshosaz J1
Authors

Source: Drug Development and Industrial Pharmacy Published:1998


Abstract

The effect of pendent side-chain length and crosslinking agent concentration in methyl methacrylate/dimethylaminoethyl methacrylate as a polybasic/hydrophobic pH-sensitive hydrogel was studied. Increasing both side-chain length and crosslinking agent concentration decreased the sharpness of response to pH and water-uptake capacity of the polymer. A case- II water transport mechanism and a nonlinear swelling kinetic was observed for the homologues of this hydrogel.
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