A H. Pylori-Independent Mir-21 Overexpression in Gastric Cancer Patients

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A H. Pylori-Independent Mir-21 Overexpression in Gastric Cancer Patients Publisher

Dehdashtian E¹ ; Tabatabaeian H^{2, 3} ; Ghaedi K^{4, 5} ; Talebi A⁶ ; Adami B⁷

Source: Gene Reports Published:2019

Abstract

Background: Gastric cancer is the third leading cause of cancer-related death worldwide. miR-21 is one of the non-coding RNAs drastically deregulated in gastric cancer. However, the expression of miR-21 and its association with the clinicopathological characteristics of gastric cancer patients has not been studied clearly in Iranian population. Objectives: We aimed to analyze the expression level of miR-21 in a set of fresh gastric cancer specimens and healthy control samples. The expression level of miR-21 was then analyzed to explore for the statistically significant correlations with the clinicopathological features of the samples. Methods: miR-21 expression level was quantitatively studied by RT-qPCR. The association studies between miR-21 expression and the clinical data were performed statistically. Results: miR-21 is highly expressed in gastric cancer patients regardless of H. pylori infection. This phenomenon significantly correlates with lymph node (p = 0.022) and peritoneal (p = 0.023) metastasis, stage I of gastric cancer (p = 0.021), greater curvature tumor location (p = 0.030) and bigger tumor size (p = 0.050) in gastric cancer patients in Iranian population. Conclusion: miR-21 is overexpressed in gastric cancer. This perturbation may not be mediated by H. pylori infection. © 2019

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Style	Citing Format
MLA	Dehdashtian E, et al.. "A H. Pylori-Independent Mir-21 Overexpression in Gastric Cancer Patients." Gene Reports, vol. 17, no. , 2019, pp. -.
APA	Dehdashtian E, Tabatabaeian H, Ghaedi K, Talebi A, Adami B (2019). A H. Pylori-Independent Mir-21 Overexpression in Gastric Cancer Patients. Gene Reports, 17(), -.
Chicago	Dehdashtian E, Tabatabaeian H, Ghaedi K, Talebi A, Adami B. "A H. Pylori-Independent Mir-21 Overexpression in Gastric Cancer Patients." Gene Reports 17, no. (2019): -.
Harvard	Dehdashtian E et al. (2019) 'A H. Pylori-Independent Mir-21 Overexpression in Gastric Cancer Patients', Gene Reports, 17(), pp. -.
Vancouver	Dehdashtian E, Tabatabaeian H, Ghaedi K, Talebi A, Adami B. A H. Pylori-Independent Mir-21 Overexpression in Gastric Cancer Patients. Gene Reports. 2019;17():-.
BibTex	@article{ author = {Dehdashtian E and Tabatabaeian H and Ghaedi K and Talebi A and Adami B}, title = {A H. Pylori-Independent Mir-21 Overexpression in Gastric Cancer Patients}, journal = {Gene Reports}, volume = {17}, number = {}, pages = {-}, year = {2019} }
RIS	TY - JOUR AU - Dehdashtian E AU - Tabatabaeian H AU - Ghaedi K AU - Talebi A AU - Adami B TI - A H. Pylori-Independent Mir-21 Overexpression in Gastric Cancer Patients JO - Gene Reports VL - 17 IS - SP - EP - PY - 2019 ER -

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