The Role of High-Density Lipoprotein in Oral and Dental Diseases Publisher Pubmed

Summary: A review suggests HDL cholesterol, beyond heart health, may also be linked to gum disease, oral cancer, and mouth healing. #OralHealth #HeartHealth

Sadeghalbanaei L¹ ; Shirban F² ; Bagherniya M^{3, 4, 5} ; Sathyapalan T⁶ ; Sahebkar A^{7, 8, 9, 10}
Source: Current Medicinal Chemistry Published:2023

Abstract

High-density lipoprotein (HDL) is the smallest and densest of the lipoproteins. Beyond its well-known cardiovascular protective function, it has other actions, including structural function, anti-inflammatory, antioxidant, anti-thrombotic effects, transport of bioactive molecules, and induction of signal transduction pathways. Further, there is a mutual connection between oral health and general health. Hence HDL could be a poten-tially crucial factor relating oral health to general health. As far as we know, no compre-hensive study has been carried out to date, which has explored the association between HDL concentration and oral diseases including lichen plan, recurrent aphthous ulcers, candidiasis, implant osseointegration, oral cancer and precancerous conditions. Here in this review, we summarized the relationship between HDL and oral health, suggesting a significant association between HDL concentration and oral health. © 2023 Bentham Science Publishers.