The Mechanisms of Long Non-Coding Rna-Xist in Ischemic Stroke: Insights Into Functional Roles and Therapeutic Potential Publisher Pubmed



Farzaneh M¹ ; Anbiyaee O² ; Azizidoost S³ ; Nasrolahi A⁴ ; Ghaedrahmati F⁵ ; Kempisty B^{6, 7, 8} ; Mozdziak P⁸ ; Khoshnam SE⁹ ; Najafi S¹⁰
Source: Molecular Neurobiology Published:2024

Abstract

Ischemic stroke, which occurs due to the occlusion of cerebral arteries, is a common type of stroke. Recent research has highlighted the important role of long non-coding RNAs (lncRNAs) in the development of cerebrovascular diseases, specifically ischemic stroke. Understanding the functional roles of lncRNAs in ischemic stroke is crucial, given their potential contribution to the disease pathology. One noteworthy lncRNA is X-inactive specific transcript (XIST), which exhibits downregulation during the early stages of ischemic stroke and subsequent upregulation in later stages. XIST exert its influence on the development of ischemic stroke through interactions with multiple miRNAs and transcription factors. These interactions play a significant role in the pathogenesis of the condition. In this review, we have provided a comprehensive summary of the functional roles of XIST in ischemic stroke. By investigating the involvement of XIST in the disease process, we aim to enhance our understanding of the mechanisms underlying ischemic stroke and potentially identify novel therapeutic targets. Graphical Abstract: (Figure presented.) © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023.