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Study of Vac a Genotypes of H.Pylori Isolated From Patients With the Upper Gastrointestinal Diseases by Pcr



Havaei SA1 ; Salehi R2 ; Fazeli SA1 ; Tavakkoli H3 ; Mohajeri P4
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Source: Journal of Isfahan Medical School Published:2009

Abstract

Background: Helicobacter pylori (H. pylori) is a gram negative curved bacilli colonized in the human stomach. It causes duodenal ulcer, gastritis and is associated with adenocarinoma. There might be a possible relationship between cagA, vacA and ice a genes and clinical outcomes. The aim of this study was to identify the frequency of vacA genotypes of H. pylori isolated from the upper gastrointestinal. Methods: One hundred H. pylori strains were isolated from patients with different gastrointestinal disease who admitted to Isfahan Al-zahra hospital. Vac A alleles were typed using PCR with specific primers. Findings: There were four Vac A mosaicsms, including 28 for s1a/m1 (28%), 23 for s1b/m1 (23%), 26 for s1a/m2 (26%) and 23 for s1b/m2 (23%), s2 form was not found. Conclusion: The results showed there is no significant relationship between different genotypes of vacA and the related diseases. © 2009, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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