Comment On: Iga Nephropathy With Early Kidney Disease Is Associated With Increased Arterial Stiffness and Renin-Angiotensin System Activity Publisher Pubmed



Mubarak M¹ ; Nasri H² ; Rafieiankopaei M³
Source: JRAAS - Journal of the Renin-Angiotensin-Aldosterone System Published:2015

Abstract

We read with great interest the article by Abdi-Ali et al. entitled IgA nephropathy with early kidney disease is associated with increased arterial stiffness and renin-angiotensin system activitya in the recent issue of Journal of the Renin-Angiotensin-Aldosterone System. In a study on 10 normotensive IgA nephropathy (IgAN) infjects with early kidney disease and 10 gender-and blood pressure-matched healthy controls, blood pressure and arterial stiffness, expressed as pulse wave velocity and aortic augmentation index, at baseline and in response to 60 min of angiotensin II (AngII) infusion were measured. They found that IgAN patients had an increased aortic augmentation index and a trend towards increased circulating renin-angiotensin system components at baseline, compared with controls. © 2015 The Author(s).