The Efficiency of Plant Extracts in the Prevention of Gastric Cancer: A Systematic Review Publisher



Rezvan M ; Hossini SE ; Sarmast K ; Khamesipour F
Source: Health Science Reports Published:2025

Abstract

Background and Aims: Gastric cancer is a global health concern with high morbidity and mortality. This systematic review evaluates the potential of plant extracts in the prevention of gastric cancer by analyzing their bioactive mechanisms. Methods: A total of 62 studies—including in vitro, in vivo, and clinical trials—were analyzed, focusing on their antiproliferative, proapoptotic, antiangiogenic, and anti-inflammatory properties. Results: Extracts such as Marsdenia tenacissima, Curcuma longa, and Rhus verniciflua showed significant promise. Conclusion: Despite these findings, issues surrounding bioavailability, dosing standardization, and long-term safety require further investigation before clinical translation. © 2025 Elsevier B.V., All rights reserved.