Organoid Technology: Current Standing and Future Perspectives Publisher Pubmed

Summary: Organoids: Mini-organs revolutionizing meds? This review traces their rise for disease modeling and drug testing, bridging 2D/in vivo gaps—boosting personalized therapies despite scalability hurdles. #Organoids #PersonalizedMedicine

Shariati L^{1, 2} ; Esmaeili Y³ ; Haghjooy Javanmard S¹ ; Bidram E^{1, 3} ; Amini A^{4, 5}
Source: Stem Cells Published:2021

Abstract

Organoids are powerful systems to facilitate the study of individuals' disorders and personalized treatments. This emerging technology has improved the chance of translatability of drugs for preclinical therapies and mimicking of the complexity of organs, proposing numerous approaches for human disease modeling, tissue engineering, drug development, diagnosis, and regenerative medicine. In this review, we outline the history of organoid technology and summarize its faithful applications, and then we discuss the challenges and limitations encountered by three-dimensional organoids. Finally, we propose that human organoids offer a basic mechanistic infrastructure for “human modeling” systems to prescribe personalized medicines. © 2021 AlphaMed Press.