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The Effects of Supplementation With L-Arginine on Anthropometric Indices and Body Composition in Overweight or Obese Subjects: A Systematic Review and Meta-Analysis Publisher



Zeinali Khosroshahi M1 ; Asbaghi O1 ; Moradi S2, 3 ; Rezaei Kelishadi M4 ; Kaviani M5 ; Mardani M6 ; Jalili C7
Authors

Source: Journal of Functional Foods Published:2020


Abstract

Background: Animal studies have shown that L-Arginine can affect anthropometric and body composition indices favorably, while results of human studies are contradictory. Objective: This is a meta-analysis of human studies in which L-arginine was provided as a dietary supplement to test its effects on anthropometric indices. Design: We searched the Cochrane library, PubMed, Embase and Scopus databases to identify studies in which L-arginine was provided to humans in randomized clinical trials. Results: Of 4784 publications, 12 trials were included for the meta-analysis. Pooled effect sizes indicated that L-arginine significantly reduced body mass index (BMI), waist circumference (WC), and fat mass (FM), and also increased fat-free mass (FFM) compared to the placebo group. However, the effects of L-arginine on body weight (BW) was not significant. Subgroup analysis could not identify factors significantly influencing BW. Conclusion: We found a beneficial effect of L-arginine supplementation on anthropometric indices in overweight and obese subjects. © 2020
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