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Quantifying the Fatal and Non-Fatal Burden of Disease Associated With Child Growth Failure, 2000–2023: A Systematic Analysis From the Global Burden of Disease Study 2023 Publisher Pubmed



Troeger CE ; Arndt MB ; Aalruz H ; Abdoun M ; Abdullahi A ; Abebe M ; Abedi A ; Abie A ; Aboagye RG ; Abolhassani H ; Abtew YD ; Abuzaid A ; Adamu LH ; Adane MM Show All Authors
Authors
  1. Troeger CE
  2. Arndt MB
  3. Aalruz H
  4. Abdoun M
  5. Abdullahi A
  6. Abebe M
  7. Abedi A
  8. Abie A
  9. Aboagye RG
  10. Abolhassani H
  11. Abtew YD
  12. Abuzaid A
  13. Adamu LH
  14. Adane MM
  15. Addo IY
  16. Adegboye OA
  17. Adekanmbi V
  18. Adetunji JB
  19. Adnani QES
  20. Adzigbli LA
  21. Afzal MS
  22. Afzal S
  23. Aggarwal N
  24. Ahmad A
  25. Ahmad MM
  26. Ahmad S
  27. Ahmadi E
  28. Ahmed A
  29. Ahmed H
  30. Ahmed MS
  31. Ahmed M
  32. Ajami M
  33. Aji B
  34. Al Hasan SM
  35. Al Omari O
  36. Alam MK
  37. Albashtawy M
  38. Alemnew F
  39. Aleyadhy A
  40. Ali MU
  41. Ali R
  42. Ali SS
  43. Ali W
  44. Almazan JU
  45. Almekhlafi HM
  46. Alsabri MA
  47. Alshahrani NZ
  48. Altaf A
  49. Alvisguzman N
  50. Alwardat M
  51. Aly H
  52. Amugsi DA
  53. Anil A
  54. Anteneh ZA
  55. Anuoluwa BS
  56. Anvari S
  57. Anyasodor AE
  58. Arabloo J
  59. Aravkin AY
  60. Areda D
  61. Arooj M
  62. Artamonov AA
  63. Arumugam A
  64. Aryntayeva N
  65. Asiamahasare BKY
  66. Athari SS
  67. Atout MMW
  68. Aweke AM
  69. Awotidebe AW
  70. Ayenew AA
  71. Azanaw MM
  72. Aziz S
  73. Babu GR
  74. Bai R
  75. Baker JL
  76. Balcha WF
  77. Banik PC
  78. Bardhan M
  79. Barrow A
  80. Bashir S
  81. Basiru A
  82. Bassat Q
  83. Bastan MM
  84. Behera P
  85. Bell ML
  86. Bemanalizadeh M
  87. Bhadoria AS
  88. Bhaskar S
  89. Bhattacharjee P
  90. Bhatti JS
  91. Bisignano C
  92. Biswas B
  93. Bodhare T
  94. Bolla SR
  95. Boppana SH
  96. Capodici A
  97. Chandika RM
  98. Chattu VK
  99. Chaudhary AA
  100. Chekole MS
  101. Chen H
  102. Cho DY
  103. Choudhari SG
  104. Chukwu IS
  105. Chung E
  106. Cruzmartins N
  107. Da Silva AG
  108. Dahiru T
  109. Dai X
  110. Dandona L
  111. Dandona R
  112. Darcho SD
  113. Darwish AH
  114. De La Hoz FP
  115. Denovagutierrez E
  116. Devanbu VGC
  117. Devegowda D
  118. Dima A
  119. Do TC
  120. Dowou RK
  121. Dy ABC
  122. El Bayoumy IF
  123. Eldegwi M
  124. Elhadi M
  125. Elilo LT
  126. El Sayed I
  127. Fasanmi AO
  128. Figueiredo M
  129. Fischer F
  130. Fomenkov AA
  131. Fraij A
  132. Gebremedhin AT
  133. Getacher L
  134. Getahun GK
  135. Gholamalizadeh M
  136. Gilbertson NM
  137. Girmay AA
  138. Golechha M
  139. Gonzalezcastell D
  140. Grivna M
  141. Guan SY
  142. Gubari MIM
  143. Gunawardane DA
  144. Guo Z
  145. Gupta B
  146. Gupta RD
  147. Haile D
  148. Hamdy NM
  149. Handal AJ
  150. Hanifi N
  151. Hareru HE
  152. Has EMM
  153. Hasaballah AI
  154. Hassan I
  155. Hay SI
  156. Hayat K
  157. He J
  158. Heibati B
  159. Heuer A
  160. Hezam K
  161. Holla R
  162. Hossain MS
  163. Hosseinzadeh H
  164. Hostiuc S
  165. Huda TM
  166. Hussain J
  167. Hussein D
  168. Huynh HH
  169. Hwang BF
  170. Ibitoye SE
  171. Immurana M
  172. Iskander TR
  173. Islam MR
  174. Islam MS
  175. Islam SMS
  176. Jacob L
  177. Jakovljevic M
  178. Jayaram S
  179. Jayatilleke AU
  180. Jin W
  181. Joseph A
  182. Joseph N
  183. Kabir A
  184. Kadashetti V
  185. Kadir DHH
  186. Kalra S
  187. Kamireddy A
  188. Kanmodi KK
  189. Kantar RS
  190. Kashoo FZ
  191. Kayode GA
  192. Kedir S
  193. Keflie TS
  194. Khan A
  195. Khan M
  196. Khanal V
  197. Khanmohammadi S
  198. Khatab K
  199. Khatatbeh MM
  200. Khatib MN
  201. Khidri FF
  202. Kim K
  203. Kim MS
  204. Kisa A
  205. Kompani F
  206. Koomson I
  207. Krishan K
  208. Kulimbet M
  209. Kumar D
  210. Kumar GA
  211. Kumar N
  212. Kumar V
  213. Kurmanova A
  214. Kurniasari MD
  215. Kusuma D
  216. Lahariya C
  217. Latief K
  218. Le MHN
  219. Le NHH
  220. Lee SW
  221. Lee SW
  222. Lee YH
  223. Ligade VS
  224. Lim SS
  225. Lin J
  226. Liu J
  227. Liu X
  228. Lodha R
  229. Lopezgil JF
  230. Lourembam SD
  231. Ma ZF
  232. Mabrok M
  233. Malhotra K
  234. Malik AA
  235. Mansouri V
  236. Manu E
  237. Marzan MB
  238. Marzo RR
  239. Marzouk S
  240. Mathur M
  241. Mattiello R
  242. Mediratta RP
  243. Mehboob R
  244. Mehta KM
  245. Mekene Meto T
  246. Mestrovic T
  247. Mettananda S
  248. Miazgowski T
  249. Minervini G
  250. Mirghafourvand M
  251. Mirica A
  252. Mohamed J
  253. Mohamed NS
  254. Mohammadalizadehcharandabi S
  255. Mohammadianhafshejani A
  256. Mohammed S
  257. Mokdad AH
  258. Monasta L
  259. Moni MA
  260. Mubarik S
  261. Mukherjee S
  262. Mulatu S
  263. Mulita F
  264. Murray CJL
  265. Mustafa G
  266. Nafei A
  267. Naik GR
  268. Natto ZS
  269. Nauman J
  270. Navaratna SNK
  271. Nayak BP
  272. Nega AT
  273. Nepal S
  274. Netsere HB
  275. Nguefacktsague G
  276. Nguyen D
  277. Nguyen TP
  278. Niazi RK
  279. Nikoobar A
  280. Nnyanzi LA
  281. Nomura S
  282. Nouri M
  283. Nriezedi CA
  284. Nurrika D
  285. Nyadanu SD
  286. Nzoputam CI
  287. Nzoputam OJ
  288. Odetokun IA
  289. Okatialiabad H
  290. Okekunle AP
  291. Okonji OC
  292. Olusanya BO
  293. Olusanya JO
  294. Osuagwu UL
  295. Ouyahia A
  296. P M
  297. Padubidri JR
  298. Pantea Stoian A
  299. Parikh RR
  300. Patel J
  301. Patil S
  302. Pawar S
  303. Pereira G
  304. Perianayagam A
  305. Petermannrocha FE
  306. Pham HN
  307. Pham HT
  308. Phan MK
  309. Pradhan J
  310. Pradhan PMS
  311. Prashant A
  312. Puvvula J
  313. Qattea I
  314. Raghav P
  315. Rahman MM
  316. Rahman M
  317. Rahman MA
  318. Rahmani AM
  319. Rahmati M
  320. Rai RK
  321. Raimondo I
  322. Rajaa S
  323. Rajabi R
  324. Ramadan MM
  325. Ramasamy C
  326. Ramasamy SK
  327. Ranabhat CL
  328. Rao CR
  329. Rao SJ
  330. Rasella D
  331. Rashid M
  332. Rathish D
  333. Rauniyar SK
  334. Rawaf DL
  335. Rawaf S
  336. Rezaei N
  337. Rezaeian M
  338. Rodrigues Da Silva TP
  339. Rodriguez JAB
  340. Rohloff P
  341. Romadlon DS
  342. Roy B
  343. Roy S
  344. Sabet CJ
  345. Sadarangani KP
  346. Saddik BA
  347. Saeed U
  348. Saghazadeh A
  349. Sagoe D
  350. Saheb Sharifaskari N
  351. Sahebkar A
  352. Sahoo PM
  353. Samodra YL
  354. Samy AM
  355. Sanjeev RK
  356. Sankararaman S
  357. Santricmilicevic MM
  358. Sarfo JO
  359. Sarikhani Y
  360. Sarkar T
  361. Sarode GS
  362. Sarode SC
  363. Sartorius B
  364. Saulam J
  365. Sawhney M
  366. Saya GK
  367. Schinckus C
  368. Schuermans A
  369. Sendekie AK
  370. Senthilkumaran S
  371. Sethi Y
  372. Seylani A
  373. Shaharudin S
  374. Shahid S
  375. Shaikh MA
  376. Sham S
  377. Shamim MA
  378. Shanawaz M
  379. Shannawaz M
  380. Sharew NT
  381. Sharma V
  382. Shetty PH
  383. Shittu A
  384. Shiue I
  385. Shorofi SA
  386. Siddig EE
  387. Sikdar M
  388. Silva LMLR
  389. Singh H
  390. Singh JA
  391. Singh K
  392. Singh S
  393. Solanki S
  394. Soni M
  395. Sorensen RJD
  396. Suleman M
  397. Sulistiyorini D
  398. Swain CK
  399. Tabatabaei SM
  400. Tabatabaeizadeh SA
  401. Tabish M
  402. Tamuzi JL
  403. Taye BT
  404. Teklehaimanot WZ
  405. Tekola A
  406. Temsah MH
  407. Thapar R
  408. Ticoalu JHV
  409. Tiruye TY
  410. Titova MV
  411. Tomo S
  412. Tovanipalone MR
  413. Tran QTH
  414. Tran TH
  415. Tran Minh Duc N
  416. Tsatsakis A
  417. Tualeka AR
  418. Ullah S
  419. Ullah S
  420. Umair M
  421. Unnikrishnan B
  422. Upadhyay E
  423. Usman JS
  424. Van Den Eynde J
  425. Vaziri S
  426. Vellingiri B
  427. Vlassov V
  428. Wagaw GB
  429. Wang Y
  430. Wu F
  431. Xiao H
  432. Yadav V
  433. Yahya G
  434. Yon DK
  435. Yonemoto N
  436. Yu C
  437. Zaman SB
  438. Zare I
  439. Zastrozhin M
  440. Zeariya MGM
  441. Zebari SMMS
  442. Zhong CC
  443. Kassebaum NJ
  444. Reiner Rc JR

Source: The Lancet Child and Adolescent Health Published:2026


Abstract

Background: Child growth failure (CGF), which includes underweight, wasting, and stunting, is among the factors most strongly associated with mortality and morbidity in children younger than 5 years worldwide. Poor height and bodyweight gain arise from a variety of biological and sociodemographic factors and are associated with increased vulnerability to infectious diseases. We used data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 to estimate CGF prevalence, the risk of infectious diseases associated with CGF, and the disease mortality, morbidity, and overall burden associated with CGF. Methods: In this analysis we estimated the all-cause and cause-specific (diarrhoea, lower respiratory tract infections, malaria, and measles) disability-adjusted life-years (DALYs) lost and mortality associated with stunting, wasting, underweight, and CGF in aggregate. We combined the burden associated with mild, moderate, and severe forms of CGF: stunting was defined as height-for-age Z scores (HAZ) less than –1, underweight was defined as weight-for-age Z scores (WAZ) less than –1, and wasting was defined as weight-for-height Z scores (WHZ) less than –1, according to WHO Child Growth Standards. Population-level continuous distributions of HAZ, WAZ, and WHZ were estimated for 2000 to 2023 using data from surveys, literature, and individual-level study data. The risk of incidence of, and mortality due to, diarrhoea, lower respiratory infections, malaria, and measles was separately estimated in a meta-regression framework from longitudinal cohort data for Z scores less than –1. Finally, fatal outcomes associated with these diseases were estimated with vital registration, verbal autopsy, and case-fatality data, while non-fatal outcomes were estimated with surveys as well as health-care utilisation and case reporting data. The exposure prevalence and relative risk estimates were from continuous distributions, allowing for direct assessment of the attributable fractions for mild, moderate, and severe stunting, underweight, wasting, and the combined impact of child growth failure within populations. All estimates were age-specific, sex-specific, geography-specific, and year-specific. Findings: We estimated that, in children younger than 5 years in 2023, CGF was associated with 79·4 million (95% uncertainty interval [UI] 47·0–106) DALYs lost and 880 000 (517 000–1 170 000) deaths. This represented 17·9% (10·6–23·8) of 444 million (434–457) total under-5 DALYs and 18·8% (11·1–25·0) of all 4·67 million (4·59–4·75) under-5 deaths. Compared to stunting (33·0 million [24·1–42·2] DALYs, 373 000 [272 000–477 000] deaths) and wasting (39·2 million [23·8–53·0] DALYs, 428 000 [256 000–583 000] deaths), childhood underweight was associated with the largest share of CGF-related disease burden: 52·2 million (21·9–75·1) DALYs and 573 000 (236 000–824 000) deaths in children younger than 5 years in 2023. Interpretation: CGF remains a leading factor associated with death and disability in children younger than 5 years, despite global attention and focused interventions to reduce the prevalence of associated CGF indicators. Our findings underscore the need for policies, strategies, and interventions that focus on all indicators of CGF to reduce its associated health burden. Funding: Gates Foundation. © 2026 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
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