Synthesis and Biological Evaluation of Bidentate 3-Hydroxypyridin-4-Ones Iron Chelating Agents

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Synthesis and Biological Evaluation of Bidentate 3-Hydroxypyridin-4-Ones Iron Chelating Agents

Saghaie L¹ ; Sadeghialiabadi H¹ ; Kafiri M¹

Source: Research in Pharmaceutical Sciences Published:2011

Abstract

A series of 3-hydroxypyridin-4-one derivatives (HPOs) were synthesized and their partition coefficient values (Kpart) were determined. The cytotoxic effects of these iron chelators against Hela cancer cells were also evaluated. The IC50 of HPOs was determined using MTT assay. Among these ligands, compound 4e (Kpart=5.02) with an IC50 of 30 μM and 4f (Kpart=0.1) with an IC50 of 700 μM showed the lowest and highest IC50s, respectively. In conclusion, the introduction of a more hydrophobic functional group (such as butyl in compound 4e) on the nitrogen of pyridinone ring resulted in higher cytotoxic activity of ligands.

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Style	Citing Format
MLA	Saghaie L, Sadeghialiabadi H, Kafiri M. "Synthesis and Biological Evaluation of Bidentate 3-Hydroxypyridin-4-Ones Iron Chelating Agents." Research in Pharmaceutical Sciences, vol. 6, no. 2, 2011, pp. -.
APA	Saghaie L, Sadeghialiabadi H, Kafiri M (2011). Synthesis and Biological Evaluation of Bidentate 3-Hydroxypyridin-4-Ones Iron Chelating Agents. Research in Pharmaceutical Sciences, 6(2), -.
Chicago	Saghaie L, Sadeghialiabadi H, Kafiri M. "Synthesis and Biological Evaluation of Bidentate 3-Hydroxypyridin-4-Ones Iron Chelating Agents." Research in Pharmaceutical Sciences 6, no. 2 (2011): -.
Harvard	Saghaie L, Sadeghialiabadi H, Kafiri M (2011) 'Synthesis and Biological Evaluation of Bidentate 3-Hydroxypyridin-4-Ones Iron Chelating Agents', Research in Pharmaceutical Sciences, 6(2), pp. -.
Vancouver	Saghaie L, Sadeghialiabadi H, Kafiri M. Synthesis and Biological Evaluation of Bidentate 3-Hydroxypyridin-4-Ones Iron Chelating Agents. Research in Pharmaceutical Sciences. 2011;6(2):-.
BibTex	@article{ author = {Saghaie L and Sadeghialiabadi H and Kafiri M}, title = {Synthesis and Biological Evaluation of Bidentate 3-Hydroxypyridin-4-Ones Iron Chelating Agents}, journal = {Research in Pharmaceutical Sciences}, volume = {6}, number = {2}, pages = {-}, year = {2011} }
RIS	TY - JOUR AU - Saghaie L AU - Sadeghialiabadi H AU - Kafiri M TI - Synthesis and Biological Evaluation of Bidentate 3-Hydroxypyridin-4-Ones Iron Chelating Agents JO - Research in Pharmaceutical Sciences VL - 6 IS - 2 SP - EP - PY - 2011 ER -

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