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The Effects of Morphine on Vascular Cell Adhesion Molecule 1(Vcam-1) Concentration in Lung Cancer Cells Publisher Pubmed



Ghasemi A1 ; Vaseghi G2 ; Hojjatallah A3 ; Haghjooy Javanmard S1
Authors

Source: Archives of Physiology and Biochemistry Published:2023


Abstract

Objective: Vascular cell adhesion molecule 1 (VCAM-1) plays an important role in tumour cell adhesion to endothelial cells. Some tumour cells also show aberrant expression of VCAM‐1. Toll-like receptor 4 (TLR4) agonists can increase VCAM-1 expression. Morphine, an opioid receptor agonist, is also a TLR4 agonist. In this study, we aimed to evaluate whether morphine increase VCAM-1 expression in a TLR4 dependent manner. Methods: A549 Lung cancer cells were treated with different doses of morphine and TLR4 antagonist for 24 and 48 h. TLR4 gene expression was evaluated by real-time PCR and VCAM-1 protein was measured by the enzyme-linked immunosorbent assay (ELISA). Results: Morphine enhanced mRNA expression of TLR4 and protein level of VCAM-1. TLR4 antagonist returned VCAM-1expression to the normal level. Conclusion: Morphine effects VCAM-1expressions via TLR4 in lung cancer cell line. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
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