Isfahan University of Medical Sciences

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Synthesis and Anti-Inflammatory Activity of New 1-Methyl-4-(4-X-Benzenesulfonyl)Pyrrolo[2,3-D] Imidazole-5-Carboxylates Pubmed



Zarghi A1 ; Ebrahimabadi AH2 ; Hassanzadeh F2 ; Heydari MR3 ; Shafiee A4
Authors

Source: Bollettino Chimico Farmaceutico Published:2003


Abstract

A series of 1-methyl-4-(4-X-arylsulfonyl)pyrrolo[2,3-d]imidazole-5-carboxylates were synthesized and tested as anti-inflammatory agents. Indomethacin was used as reference drug. Two of the synthesized compounds 7a and 7b had an effect equal to 0.1 of indomethacin. Our result showed that the electron-withdrawing substituents in the para position of the benzensulfonyl moiety increase activity.