Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Autoimmunity in Common Variable Immunodeficiency: Epidemiology, Pathophysiology and Management Publisher Pubmed



Azizi G1, 2, 3 ; Abolhassani H2, 4 ; Asgardoon MH2, 5 ; Alinia T2 ; Yazdani R6 ; Mohammadi J7 ; Rezaei N2 ; Ochs HD8 ; Aghamohammadi A2, 3
Authors

Source: Expert Review of Clinical Immunology Published:2017


Abstract

Introduction: Common variable immunodeficiency (CVID) comprises a large heterogeneous group of patients with primary antibody deficiency. Areas covered: The affected patients are characterized by increased susceptibility to infections and low levels of serum immunoglobulin. However, enteropathy, granulomatous organ infiltrates, malignancy, inflammatory and autoimmune conditions are also prevalent. The concomitance of immunodeficiency and autoimmunity appears to be paradoxical and creates difficulties in the management of autoimmune complications affecting these patients. Expert commentary: The management of autoimmunity in patients with CVID requires special considerations because dysregulation and dysfunctions of the immune system along with persistent inflammation impair the process of diagnosis and treatment. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. Approach to the Management of Autoimmunity in Primary Immunodeficiency, Scandinavian Journal of Immunology (2017)
2. Autoimmunity in Primary Antibody Deficiencies, International Archives of Allergy and Immunology (2017)
3. Long-Term Evaluation of a Historical Cohort of Iranian Common Variable Immunodeficiency Patients, Expert Review of Clinical Immunology (2014)
Experts (# of related papers)
View all Related Experts
Mazdak Ganjalikhani Hakemi (6)
Abbas Rezaei (3)
Other Related Docs
4. T-Cell Abnormalities in Common Variable Immunodeficiency, Journal of Investigational Allergology and Clinical Immunology (2016)
5. Noninfectious Complications in B-Lymphopenic Common Variable Immunodeficiency, Journal of Investigational Allergology and Clinical Immunology (2024)
6. Abnormality of Regulatory T Cells in Common Variable Immunodeficiency, Cellular Immunology (2017)
7. Evaluation of Known Defective Signaling-Associated Molecules in Patients Who Primarily Diagnosed As Common Variable Immunodeficiency, International Reviews of Immunology (2016)
8. Epidemiology and Pathophysiology of Malignancy in Common Variable Immunodeficiency?, Allergologia et Immunopathologia (2017)
9. Comparison of Various Classifications for Patients With Common Variable Immunodeficiency (Cvid) Using Measurement of B-Cell Subsets, Allergologia et Immunopathologia (2017)
10. A Review on Defects of Dendritic Cells in Common Variable Immunodeficiency, Endocrine, Metabolic and Immune Disorders - Drug Targets (2017)
11. Important Factors Influencing Severity of Common Variable Immunodeficiency, Archives of Iranian Medicine (2016)
12. The Use of Immunoglobulin Therapy in Primary Immunodeficiency Diseases, Endocrine, Metabolic and Immune Disorders - Drug Targets (2016)
13. A Comparison of Clinical and Immunologic Phenotypes in Familial and Sporadic Forms of Common Variable Immunodeficiency, Scandinavian Journal of Immunology (2017)
14. Role of Rare Immune Cells in Common Variable Immunodeficiency, Pediatric Allergy and Immunology (2022)
15. Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency, Clinical Immunology (2017)
16. Autoimmunity in Primary T-Cell Immunodeficiencies, Expert Review of Clinical Immunology (2016)
17. Role of Apoptosis in the Pathogenesis of Common Variable Immunodeficiency (Cvid), Endocrine, Metabolic and Immune Disorders - Drug Targets (2017)
18. Decreased Expression of B Cell Maturation Antigen in Patients With Common Variable Immunodeficiency, Pediatric, Allergy, Immunology, and Pulmonology (2017)
19. Infectious and Noninfectious Pulmonary Complications in Patients With Primary Immunodeficiency Disorders, Journal of Investigational Allergology and Clinical Immunology (2017)
20. Role of Apoptosis in Common Variable Immunodeficiency and Selective Immunoglobulin a Deficiency, Molecular Immunology (2016)