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Effect of a Pro-Fertility Diet Combined With Omega-3 Supplementation on Embryo Quality in Infertile Women Undergoing Ivf: A Randomized Controlled Trial Publisher Pubmed

Summary: Can diet affect IVF outcomes? In a 180-woman trial, a fertility diet plus supplements improved fertilization and embryo quality, though live-birth benefits remain unknown. #IVF #Nutrition

Ghadimi Yari M ; Ghasemi Tehrani H ; Feizi A ; Ziaei R ; Derakhshan M ; Rouhani M H
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Source: Reproductive BioMedicine Online Published:2026


Abstract

Research question: Does adherence to a pro-fertility diet (PFD) combined with omega-3 supplementation improve the fertilization rate and embryo quality in infertile women undergoing IVF? Design: A randomized, single-blind, parallel clinical trial was conducted from June 2024 to June 2025 among 180 infertile women aged 18–42 years undergoing IVF at Hazrat Maryam Fertility Center, Isfahan, Iran. Participants were randomized (1:1) to receive either a structured PFD with daily omega-3 (1000 mg), vitamin D (1000 IU), folate (1 mg) and vitamin B12 (500 µg) supplementation for 60 days, or general dietary advice based on the Healthy Eating Plate model plus 500 µg/day folic acid. Fertilization rate, embryo formation rate and embryo quality (grades A–D) were evaluated. Results: Compared with controls, the intervention group had significantly higher fertilization rates (0.81 ± 0.16 versus 0.66 ± 0.24; P < 0.001) and embryo formation rates (0.79 ± 0.26 versus 0.62 ± 0.30; P < 0.001), and an increased number of embryos formed (3.78 ± 2.34 versus 2.22 ± 1.46; P < 0.001). Additionally, the proportion of grade A embryos was markedly higher in the intervention group (45.2% versus 21.7%; P = 0.003). Conclusion: Adherence to a PFD combined with omega-3 supplementation significantly improved the fertilization rate and embryo quality in women undergoing IVF. This combined nutritional intervention represents a safe, feasible and cost-effective adjunctive approach to optimize embryological outcomes in assisted reproductive technology. © 2026 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
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