Synthesis and Antileishmanial Activity of Antimony (V) Complexes of Hydroxypyranone and Hydroxypyridinone Ligands Publisher



Sheikhmoradi V¹ ; Saberi S² ; Saghaei L¹ ; Pestehchian N² ; Fassihi A¹
Source: Research in Pharmaceutical Sciences Published:2018

Abstract

A novel series of antimony (V) complexes with the hydroxypyranone and hydroxypyridinone ligands were synthesized and characterized by 1HNMR, FT-IR and electron spin ionization mass spectroscopic (ESI-MS) techniques. The synthesis process involved protection of hydroxyl group followed by the reaction of the intermediate with primary amines and finally deprotection. All compounds were evaluated for in vitro activities against the amastigote and promastigote forms of Leishmania major. Most of the synthesized compounds exhibited good antileishmanial activity against both forms of L. major. IC50 values of the most active compounds; 9d, 9d and 9e, after 24, 48 and 72 h against amastigote model were 15, 12.5 and 5.5 μg/mL, respectively. 9e, 11 and 9e inhibited the promastigote form of parasite after 24, 48 and 72 h with IC50 values of 10, 2 and 1 μg/mL, respectively. © 2018 Medknow Publications. All rights reserved.