Prevalence of Congenital Hypothyroidism in Isfahan, Iran: Results of a Survey on 20,000 Neonates Publisher Pubmed



Hashemipour M^{1, 2, 6} ; Amini M^{1, 2} ; Iranpour R² ; Sadri GH³ ; Javaheri N¹ ; Haghighi S¹ ; Hovsepian S¹ ; Javadi AA⁴ ; Nematbakhsh M⁵ ; Sattari G¹
Source: Hormone Research Published:2004

Abstract

Aims: To evaluate the prevalence of congenital hypothyroidism (CH) in a screening program performed for the first time in Isfahan, Iran. Methods: From May 2002 to December 2002, T4 and TSH serum concentrations of 20,000 3- to 7-day-old newborns, born in all 17 hospitals of the city, were measured by radioimmunoassay and immunoradiometric assay, respectively. The newborns with abnormal screening results (TSH >20 mIU/l, T4 <6.5 μg/dl and based on the weight) were re-examined. Results: Of 531 recalled subjects (recall rate 2.6%), 54 were confirmed to be hypothyroid, showing a prevalence of 1:370 for CH. Conclusion: Considering the high frequency of CH, the necessity of implementing a routine screening program in the healthcare system of Isfahan Province is emphasized. Copyright © 2004 S. Karger AG, Basel.