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Circular Rnas: Pivotal Role in the Leukemogenesis and Novel Indicators for the Diagnosis and Prognosis of Acute Myeloid Leukemia Publisher



Rahmati A1, 2 ; Mafi A3 ; Soleymani F4 ; Babaei Aghdam Z5 ; Masihipour N6 ; Ghezelbash B7 ; Asemi R8 ; Aschner M9 ; Vakili O3 ; Homayoonfal M10 ; Asemi Z10 ; Sharifi M8 ; Azadi A11 ; Mirzaei H10 Show All Authors
Authors
  1. Rahmati A1, 2
  2. Mafi A3
  3. Soleymani F4
  4. Babaei Aghdam Z5
  5. Masihipour N6
  6. Ghezelbash B7
  7. Asemi R8
  8. Aschner M9
  9. Vakili O3
  10. Homayoonfal M10
  11. Asemi Z10
  12. Sharifi M8
  13. Azadi A11
  14. Mirzaei H10
  15. Aghadavod E10, 12

Source: Frontiers in Oncology Published:2023


Abstract

Acute myeloid leukemia (AML) is an aggressive hematological malignancy and affected patients have poor overall survival (OS) rates. Circular RNAs (circRNAs) are a novel class of non-coding RNAs (ncRNAs) with a unique loop structure. In recent years, with the development of high-throughput RNA sequencing, many circRNAs have been identified exhibiting either up-regulation or down-regulation in AML patients compared with healthy controls. Recent studies have reported that circRNAs regulate leukemia cell proliferation, stemness, and apoptosis, both positively and negatively. Additionally, circRNAs could be promising biomarkers and therapeutic targets in AML. In this study, we present a comprehensive review of the regulatory roles and potentials of a number of dysregulated circRNAs in AML. Copyright © 2023 Rahmati, Mafi, Soleymani, Babaei Aghdam, Masihipour, Ghezelbash, Asemi, Aschner, Vakili, Homayoonfal, Asemi, Sharifi, Azadi, Mirzaei and Aghadavod.
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