Long Non-Coding Rnas Involved in Retinoblastoma Publisher Pubmed



Nasrolahi A¹ ; Azizidoost S² ; Radoszkiewicz K³ ; Najafi S⁴ ; Ghaedrahmati F⁵ ; Sheykhisabzehpoush M⁶ ; Poodineh J⁷ ; Hajizadeh M^{1, 8} ; Anbiyaiee A⁹ ; Farzaneh M¹⁰ ; Feghhi M^{1, 8}
Source: Journal of Cancer Research and Clinical Oncology Published:2023

Abstract

Introduction: Retinoblastoma (RB) is the most common childhood tumor that can occur in the retina and develop in a sporadic or heritable form. Although various traditional treatment options have been used for patients with RB, identifying novel strategies for childhood cancers is necessary. Material and methods: Recently, molecular-based targeted therapies have opened a greater therapeutic window for RB. Long non-coding RNAs (lncRNAs) presented a potential role as a biomarker for the detection of RB in various stages. Conclusion: LncRNAs by targeting several miRNA/transcription factors play critical roles in the stimulation or suppression of RB. In this review, we summarized recent progress on the functions of tumor suppressors or oncogenes lncRNAs in RB. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.