Effects of Decellularized Extracellular Matrix on Polyhydroxybutyrate Electrospun Scaffolds for Cartilage Tissue Engineering Publisher

Summary: A study found adding cartilage material to scaffolds improves cartilage repair, aiding joint health. #JointHealth #TissueEngineering

Asgharivostakolaei M¹ ; Bahramian H¹ ; Karbasi S² ; Setayeshmehr M³
Source: Polymer-Plastics Technology and Materials Published:2023

Abstract

The current study was carried out to evaluate the effects of cartilage-decellularized extracellular matrix (ECM) on Poly (3-hydroxybutyrate) (PHB) electrospun scaffold for cartilage tissue engineering. In this study, PHB scaffolds with three different percentages of ECM (1%, 2%, and 3%) were fabricated. Mechanical, chemical, and physical properties of scaffolds along with their interactions with cells were assessed. Results showed that by adding of ECM to the scaffolds, the Physiomechanical properties of combined scaffolds were modified, compared to the pure PHB scaffold. In the other hand, the biological behavior was increased by increasing the ECM ratio to the PHB. © 2022 Taylor & Francis.