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Novel 16,17-Epoxy-23-Methylergostane Derivative From Sinularia Variabilis, a Soft Coral From the Persian Gulf, With Apoptotic Activities Against Breast Cancer Cell Lines Publisher Pubmed

Summary: A study found a new coral compound kills breast cancer cells by disrupting cell energy, showing promise. #CancerResearch #BreastCancer

Mohammadi Pour P1 ; Yegdaneh A1 ; Aghaei M2 ; Ali Z3 ; Khan IA3 ; Ghanadian M4
Authors

Source: Natural Product Research Published:2022


Abstract

The steroidal and terpenoidal composition of Sinularia variabilis was investigated by chromatography methods. One new (1), and four known [gorgasta-5-en-3β-ol (2), ergosta-5-en-3β-ol (3), ergosta-5, 22(Z)-dien-3β-ol (4), 5,8-epidioxy-5α, 8α-ergosta-6, 22E-dien-3β-ol (5)] steroids, in addition to one known diterpenoidal alkaloid [sinulasulfone (6)] isolated for the first time from S. variabilis. If we named the 23-methylergostane core structure as sinustane, new compound (1) was elucidated as 16α,17α-epoxysinusta-5-en-3β–ol-20β-yl sulfate based on NMR and HR Mass data. It was submitted for cytotoxic activity evaluation against MCF-7 and MDA-MB-231 cell lines using MTT assay. Apoptosis induction was checked by flow cytometry (annexin V/propidium iodide) staining. To determine the production of reactive oxygen species, and the mitochondrial transmembrane potential (ΔΨm), the DCFDA, and JC‐1 probes were used in this study. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
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