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Preparation and Evaluation of Theophylline Sustained Release Microcapsules Using Coacervation Publisher



Ghaffari S1, 2, 3, 4 ; Alamdari NS3 ; Azar ZJ3 ; Da Siaghi ARB3 ; Kobarfard F5 ; Ghaffari S1, 2, 3, 4
Authors

Source: Journal of Dispersion Science and Technology Published:2012


Abstract

Preparation of sustained release dosage forms is one of the main objectives in drug formulation. Theophylline that has a narrow therapeutic index, making it a good choice to prepare a sustained release dosage form. Theophylline sustained release microcapsules were prepared by applying the coacervation method. The effect of the type and ratio of polymers, as well as the type of washing solvents, was studied on particle size, drug loading efficiency, and in vitro drug release profile. Results showed that Eudragit RS and RL could be more suitable polymers for preparation of sustained release microcapsules of theophylline when used in ratio of 1:1 and when the washing solvent was hexane. © 2012 Copyright Taylor and Francis Group, LLC.
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