Association of Rs8066560 Variant in the Sterol Regulatory Element-Binding Protein 1 (Srebp-1) and Mir-33B Genes With Hyperglycemia and Insulin Resistance Publisher Pubmed



Nikpour P^{1, 2, 3} ; Miranzadehmahabadi H⁴ ; Emadibaygi M^{4, 5} ; Kelishadi R¹
Source: Journal of Pediatric Endocrinology and Metabolism Published:2014

Abstract

Objective: This study aims to evaluate the association of miR-33b/SREBP-1 rs8066560 with hyperglycemia and insulin resistance in Iranian children and adolescents.; Methods: This case-control study comprised 200 participants with 9-19 years of age, consisting of 100 MetS and 100 healthy controls. Anthropometric and biochemical parameters were measured, and the polymorphism was genotyped by TaqMan real-time PCR method.; Results: Logistic regression analysis of genotype distribution of rs8066560 did not show a significant association with MetS neither in boys (OR, 1.745; 95% CI, 0.695-4.382; p = 0.236) nor in girls (OR, 1.075; 95% CI, 0.420-2.752; p = 0.880). Participants with GG/AG genotypes had significant higher LDL-C levels than those with the AA genotype. No statistically significant difference was documented in fasting blood glucose and insulin levels between the three rs8066560 genotypes.; Conclusions: We found that rs8066560 variant on SREBP-1 and miR-33b genes is associated with LDL-C levels; however, it may not be an important determinant for the MetS, hyperglycemia, and insulin resistance in children and adolescents.