Effects of Curcumin on Low-Density Lipoprotein Oxidation: From Experimental Studies to Clinical Practice Publisher



Baratzadeh F^{1, 2} ; Butler AE³ ; Kesharwani P⁴ ; Moallem SA^{5, 6} ; Sahebkar A^{7, 8, 9, 10}
Source: EXCLI Journal Published:2022

Abstract

Atherosclerosis is the most frequent cause of death globally. Oxidized low-density lipoprotein (ox-LDL) has an essential role in the formation of atherosclerotic plaques and foamy macrophages. Ox-LDL increases the uptake of cholesterol by macrophages and is the major cause of blood flow disruption. Ox-LDL is produced during oxi-dative stress and treatment with antioxidants could inhibit the production and function of ox-LDL. Curcumin is a potent antioxidant and has a strong track record in the treatment of numerous diseases. Recent studies indicate that Curcumin exerts a lipid-lowering effect, and can modulate the formation of atherosclerotic plaque. The current review focuses upon the role of Curcumin in oxidation of LDL and foam cell formation in atherosclerotic lesions. © 2022, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved.