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Effect of Acupuncture Treatment on Level of Serum Interferon (Ifn)-Γ in Balb/C Model of Leishmania Major Infection



Shakibapour M1 ; Ghaffari Hoseini S2 ; Mahmoodi M3 ; Rostami F4 ; Hejazi SH5
Authors

Source: Journal of Isfahan Medical School Published:2013

Abstract

Background: Cutaneous leishmaniasis (CL) is an endemic parasitic disease in Iran. Current treatments for the disease are not satisfying, have many side effects and are expensive. The healing effect of T-helper 1 (Th1) immune response, especially interferon (IFN)-γ secretion in CL has been previously documented. It has been shown that acupuncture, a traditional Chinese medicine, also might activate Th1 immune response. In this study, the effect of acupuncture on serum level of IFN-γ in experimental CL of BALB/c mice was investigated. Methods: 60 BALB/c mice were experimentally infected with Leishmania major and assigned randomly in to three groups: acupuncture treatment group which were given the acupuncture (thirty minutes daily, two days a week for 10 sessions) and intra-peritoneal diazepam, as a sedative agent; control group for diazepam which only received the diazepam; and a control group without any intervention. Serum level of IFN-γ was measured by means of ELISA at the beginning of the study and at sessions 5 and 10 of acupuncture treatment in three groups. Findings: The mean serum level of IFN-γ was not significantly different between and within the groups at the beginning and at the sessions 5 and 10 of the therapy. Conclusion: This investigation showed that acupuncture may not affect the serum level of IFN-γ in BALB/c model of CL. Moreover, diazepam does not interfere with the serum level of IFN-γ in such a study. Analysis of other immune factors and early measurement of IFN-γ in the course of treatment possibly may display the activated protective immune response against leishmaniasis by acupuncture.
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