A Review of Controlled Drug Delivery Systems Based on Cells and Cell Membranes Publisher

Summary: Review highlights cells like erythrocytes as promising drug delivery systems with high biocompatibility. #DrugDelivery #CellTherapy

Zargar SM¹ ; Hafshejani DK² ; Eskandarinia A² ; Rafienia M³ ; Kharazi AZ²
Source: Journal of Medical Signals and Sensors Published:2019

Abstract

Novel drug delivery systems have ameliorated drugs' pharmacokinetics and declined undesired ramifications while led to a better patient compliance by extending the time of release. In fact, although there has been a multitude of encouraging achievements in controlled drug release, the application of micro- and nano-carriers is confronted with some challenges such as rapid clearance and inefficient targeting. In addition, since cell systems can be an appropriate alternative to micro- and nano-particles, they have been used as biological carriers. In general, features such as stable release into blood, slow clearance, efficient targeting, and high biocompatibility are the main properties of cells applied as drug carriers. Furthermore, some cells such as erythrocytes, leukocytes, stem cells, and platelets have been used as release systems. Hence, most common cells that were used as aforementioned release systems are going to be presented in this review article. © 2019 Journal of Medical Signals & Sensors.