Effect of Nigella Sativa Oil Extract on Cardiometabolic Risk Factors in Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Publisher Pubmed

Summary: Study shows Nigella sativa oil lowers blood sugar, cholesterol, and blood pressure in type 2 diabetes patients. #Diabetes #NigellaSativa

Hadi S¹ ; Daryabeygikhotbehsara R² ; Mirmiran P³ ; Mcvicar J² ; Hadi V⁴ ; Soleimani D⁵ ; Askari G^{1, 6}
Source: Phytotherapy Research Published:2021

Abstract

The objective of this study was to determine the effects of Nigella sativa oil extract on cardiometabolic risk factors in people with type 2 diabetes (T2D). A randomized, controlled, clinical trial was conducted on 43 patients with T2D (23 women and 20 men; aged 53.5 ± 7.4 years). The intervention group (N = 23) received two 500-mg per day soft gel capsules containing Nigella sativa oil extract and the control group (N = 20) received two identical placebo soft gel capsules containing sunflower oil per day for the same period, 8 weeks. Pre- and post-intervention cardiometabolic risk factors were measured. Compared with the placebo, the N. sativa oil significantly decreased FBS (p =.03(, HbA1c (p =.001), total cholesterol (p =.04), TG (p =.003), LDL-c (p =.001), BMI (p <.001), waist circumference (p <.001), SBP (p =.001), and DBP (p =.002). HOMA-IR (p =.51) and HDL-c (p =.91) did not change significantly following Nigella sativa supplementation. Nigella sativa oil exerted beneficial effects on glycemic control, serum lipid profile, blood pressure, and body weight among people with T2D. Further long-term trials in the future may help confirm the current therapeutic benefits of Nigella sativa in T2D. © 2021 John Wiley & Sons, Ltd.