A Novel Mutation in Slc3a1 Gene in Patients With Cystinuria Pubmed

Summary: Study discovers new SLC3A1 gene mutation in cystinuria patients. Could this aid early diagnosis? #KidneyDisease #Genetics

Markazi S¹ ; Kheirollahi M² ; Doosti A¹ ; Mohammadi M³ ; Koulivand L²
Source: Iranian Journal of Kidney Diseases Published:2016

Abstract

Cystinuria is an inherited disease characterized by the formation of cystine calculi in the kidneys, ureters, and bladder. Cystinuria is associated with mutation in the SLC3A1 and SLC7A9 genes. These defects prevent appropriate reabsorption of dibasic amino acids lysine, ornithine and arginine. Cystinuria is classified as type I (silent heterozygotes) and non-type I (heterozygotes with urinary hyperexcretion of cystine). In molecular term, cystinuria is classified as type A (mutations on SLC3A1 gene) and type B (mutations on SLC7A9 gene). This report describes 7 patients with early onset of cystine calculus formation. We are report a new mutation in SLC3A1 gene in exon 1. A novel nucleotide substitution c.-29A>G was found in exon 1 of the SLC3A1 gene, which had not been reported elsewhere previously. © 2016, Iranian Society of Nephrology. All Rights Reserved.