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Effects of Greater Occipital Nerve Block With Local Anesthetic and Triamcinolone for Treatment of Medication Overuse Headache: An Open-Label, Parallel, Randomized, Controlled Clinical Trial Publisher Pubmed



Arab A1 ; Khoshbin M2 ; Karimi E3, 4 ; Saberian G5 ; Saadatnia M6 ; Khorvash F6
Authors

Source: Neurological Sciences Published:2022


Abstract

Aim: There is a paucity of evidence and consensus on exactly how to carry out the detoxification process. To examine the effect of a greater occipital nerve block (GONB) in the detoxification process, we conducted an open-label, parallel, randomized, controlled clinical trial. Materials and methods: In order to conduct this study, 54 medication-overuse headache (MOH) patients were recruited and allocated randomly to group A (n = 27) or B (n = 27). In both groups, patients underwent detoxification processes without any acute migraine medication or analgesics. During the run-in period, all patients in both groups received the same education, managed by a neurologist and nutritionist. All patients were offered maximally 300 mL of promethazine syrup (5 mg/5 mL) to be taken 10 mg every 8 h during the first 10 days of the study. A 2-mL syringe containing 1 mL of lidocaine 2% and 1 mL of triamcinolone 40 mg/mL was prepared for each patient of group A for conducting GONB. Characteristics of headache attacks, including headache severity, frequency, and duration, were assessed at baseline and after 3 months of intervention. Results: Twenty-six patients in group A (96.3%) and twenty-three in group B (85.2%) completed detoxification, and were thus cured of MOH (P = 0.351). The present study revealed that GONB with local anesthetic and triamcinolone significantly improved the characteristics of headache, including frequency (− 13.66 in group A and − 7.55 in group B), duration (− 7.92 in group A and − 5.88 in group B), and severity (− 3.44 in group A vs. − 1.33 in group B) in group A compared to control (all P value < 0.05). Conclusions: Although both detoxification programs were effective, detoxification with GONB resulted in better outcomes. Trial registration: Iranian Registry of Clinical Trials (registration number; IRCT20150906023922N2) © 2021, Fondazione Societa Italiana di Neurologia.
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