Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Role of Fenofibrate in Restoring Angiogenesis in Diabetic and Control Hind Limb Ischemic Rats Publisher Pubmed



Salehi E1 ; Khazaei M1 ; Rashidi B2
Authors

Source: General Physiology and Biophysics Published:2012


Abstract

In this study, we examined the effect offenofibrate, an agonistof peroxisome proliferator-activated receptor α (PPARα), on angiogenesis and serum nitric oxide (NO), vascular endothelial growth factor (VEGF) and VEGF receptor-2 (VEGFR-2) in diabetic and control hind limb ischemic rats. Male Wistar rats underwent lef hind limb ischemia. The experimental groups consisted of rats: control, diabetic, control receiving fenofibrate (100 mg/kg/day, by gavage) and diabetic receiving fenofibrate. Afer 21 days, blood samples were taken and capillary density and capillary/fiber ratio of the ischemic hind limb muscle was evaluated by immunohistochemistry. Activation of PPARα by fenofibrate restored neovascularization in diabetic and control hind limb ischemic rats (p < 0.05). Fenofibrate administration significantly increased serum nitrite concentration, the main metabolite of NO, without significant changes in serum VEGF and VEGFR-2 concentrations. It seems that fenofibrate enhances angiogenesis in hind limb ischemia possibly through increasing of NO bioavailability and can be considered for treatment of diabetic peripheral vascular diseases in future human studies.
Related Docs
View other Related Docs
1. Pan-Ppar Agonist, Bezafibrate, Restores Angiogenesis in Hindlimb Ischemia in Normal and Diabetic Rats, International Journal of Peptides (2012)
2. Rosiglitazone Enhances Neovascularization in Diabetic Rat Ischemic Hindlimb Model, Biomedical Papers (2012)
3. Myocardial Capillary Density in Normal and Diabetic Male Rats: Effect of Bezafibrate, Research in Pharmaceutical Sciences (2013)
Experts (# of related papers)
View all Related Experts
Shaghayegh Haghjooy Javanmard (5)
Bahman Rashidi (5)
Other Related Docs
4. Effect of Rosiglitazone on Coronary Angiogenesis in Diabetic and Control Rats, Journal of Isfahan Medical School (2011)
5. Angiogenesis in Health and Disease: Role of Vascular Endothelial Growth Factor (Vegf), Journal of Isfahan Medical School (2011)
6. Effect of Peroxisome Proliferator-Activated Receptor Agonists on Serum Inflammatory Markers in Diabetic Rats, Journal of Isfahan Medical School (2014)
7. Role of Gw0742 a Pparβ/Δ Agonist on Coronary Angiogenesis in Control and Diabetic Rats, Journal of Isfahan Medical School (2011)
8. Inducible Nitric Oxide Synthase Modulates Angiogenesis in Ischemic Hindlimb of Rat, Biomedical Papers (2009)
9. Effect of Peroxisome Proliferator-Activated Receptors on Cardiac Remodeling in Normal and Diabetic Rats, Journal of Isfahan Medical School (2014)
10. Role of Peroxisome Proliferator-Activated Receptor Β Agonist on Angiogenesis in Hindlimb Ischemic Diabetic Rats, Journal of Diabetes and its Complications (2012)
11. Imbalance of Angiogenesis in Diabetic Complications: The Mechanisms, International Journal of Preventive Medicine (2012)
12. Changes of Plasma Angiogenic Factors During Chronic Resistance Exercise in Type I Diabetic Rats, Pakistan Journal of Medical Sciences (2012)
13. Effects of Diabetes on Myocardial Capillary Density and Serum Angiogenesis Biomarkers in Male Rats, Clinics (2011)
14. Limbs’ Postischemic Revascularization Is Not Improved by Losartan Treatment in Diabetic Rats, Endocrine Regulations (2014)
15. Fenofibrate, a Peroxisome Proliferator-Activated Receptor Alpha, Improves Myocardial Capillary Density in Diabetic Rats., JPMA. The Journal of the Pakistan Medical Association (2012)
16. Restoration of Angiogenesis by Enalapril in Diabetic Hindlimb Ischemc Rats, Biomedical Papers (2011)
17. Role of Peroxisome Proliferator-Activated Receptor Alpha and Gamma in Antiangiogenic Effect of Pomegranate Peel Extract, Iranian Journal of Basic Medical Sciences (2016)
18. Role of Angiotensin Type 2 Receptor on Nitric Oxide Production Response to Angiotensin Ii Administration in Ovariectomised Rats Treated With Estradiol, International Journal of Preventive Medicine (2014)
19. The Effects of Salsalate on Biochemical Factors of Serum and Endothelial Dysfunction in Patients With Newly Diagnosed Type 2 Diabetes, Journal of Isfahan Medical School (2012)
20. The Effects of Mas Receptor Antagonist (A779) and Renal Perfusion Pressure on Serum Nitrite Concentration in Male and Female Rats When Angiotensin Ii Receptors 1 & 2 Were Blocked, Physiology and Pharmacology (2015)