Pbmcs: A New Source of Diagnostic and Prognostic Biomarkers Publisher Pubmed



Mosallaei M¹ ; Ehtesham N¹ ; Rahimirad S¹ ; Saghi M² ; Vatandoost N¹ ; Khosravi S¹
Source: Archives of Physiology and Biochemistry Published:2022

Abstract

There are various types of molecular biomarkers that are derived from distinct starting materials. Although many indirect biomarkers are found in blood, their detection remains a challenging issue because of the high degree of fragmentation, minute quantity and a vast amount of non-specific background. The present review points out the sensitivity and specificity of peripheral blood mononuclear cells (PBMCs) as an intact source of biomarkers in a variety of diseases. Multiple recent studies that have used PBMCs as a source of biomarkers reveal the alteration of mRNAs/microRNAs (miRNAs) signature and methylation profile in many kinds of disorders; for instance, dysregulation of mRNAs/miRNAs in schizophrenia, diabetes and different types of cancers and change in the methylation status of LINE-1 in neoplasms. In conclusion with a strong probability, PBMCs mimic conditions of some tissues which are in contact with them like the tumour cells, hence providing a non-invasive and suitable source of biomarkers. © 2020 Informa UK Limited, trading as Taylor & Francis Group.