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Cerium Oxide Nanoparticles: A Promising Tool for the Treatment of Fibrosarcoma In-Vivo Publisher Pubmed



Nourmohammadi E1, 2 ; Khoshdelsarkarizi H3 ; Nedaeinia R4 ; Darroudi M5 ; Kazemi Oskuee R6
Authors

Source: Materials Science and Engineering C Published:2020


Abstract

In this study, we used cerium oxide nanoparticles and evaluated their anti-cancer effects in a mouse model of fibrosarcoma. For evaluation of anti-cancer effects of nanoceria, tumor volume measurement, TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) assay, quantitative real-time PCR (qPCR) for Bax and Bcl2 genes, a panel of liver and kidney function tests and hematoxylin-eosin staining were done. Nanoceria dominantly accumulated in the tumor and it could significantly decrease tumor growth and volume in tumor-bearing mice that received nanoceria for four weeks. Cerium oxide nanoparticle showed potential anti-cancer properties against fibrosarcoma. © 2019 Elsevier B.V.