An Updated Overview of the Application of Car-T Cell Therapy in Neurological Diseases Publisher



Shahabifard H¹ ; Zarei M² ; Kookli K³ ; Esmalian Afyouni N⁴ ; Soltani N⁵ ; Maghsoodi S⁶ ; Adili A⁷ ; Mahmoudi J¹ ; Shomali N⁸ ; Sandoghchian Shotorbani S⁸
Source: Biotechnology Progress Published:2023

Abstract

Genetically modified immune cells, especially CAR-T cells, have captured the attention of scientists over the past 10 years. In the fight against cancer, these cells have a special place. Treatment for hematological cancers, autoimmune disorders, and cancers must include CAR-T cell therapy. Determining the therapeutic targets, side effects, and use of CAR-T cells in neurological disorders, including cancer and neurodegenerative diseases, is the goal of this study. Due to advancements in genetic engineering, CAR-T cells have become crucial in treating some neurological disorders. CAR-T cells have demonstrated a positive role in treating neurological cancers like Glioblastoma and Neuroblastoma due to their ability to cross the blood–brain barrier and use diverse targets. However, CAR-T cell therapy for MS diseases is being researched and could be a potential treatment option. This study aimed to access the most recent studies and scientific articles in the field of CAR-T cells in neurological diseases and/or disorders. © 2023 American Institute of Chemical Engineers.