Precision in Cancer Diagnostics: Ultra-Sensitive Detection of Mcf-7 Breast Cancer Cells by Gold Nanostructure-Enhanced Electrochemical Biosensing Publisher Pubmed

Summary: Gold nanostructure-based biosensor detects MCF-7 breast cancer cells with high sensitivity and stability. #BreastCancer #Biosensor

Rahmanipour M¹ ; Siampour H³ ; Moshaii A^{1, 2} ; Amirabadizadeh M⁴ ; Fouani MH⁴ ; Shariati L^{5, 6} ; Rafienia M³
Source: Journal of Materials Chemistry B Published:2024

Abstract

Timely identification of cancers is pivotal in optimizing treatment efficacy and reducing their widespread impact. This study introduces a novel biosensor for the sensitive electrochemical detection of cancer cells overexpressing mucin 1 (MUC1), a well-established model for breast cancer. The sensor substrate comprises gold columnar nanostructures obtained through glancing angle deposition (GLAD) of copper nanostructures, subsequently replaced by gold via a facile galvanic replacement process. Functionalizing these gold nanostructures with aptamers targeting the MUC1 glycoproteins, a prominent cancer biomarker, enables specific recognition of MCF-7 breast cancer cells. The proposed electrochemical sensing platform offers several advantages, including high selectivity, a wide linear range of detection, a low detection limit of 30 cells per mL, and long-term stability, rendering this sensor highly desirable for definitive breast cancer diagnosis. © 2024 The Royal Society of Chemistry.