Lineage and Sublineage Analysis of Human Papillomavirus Types 51 and 59 in Iranian Women Publisher Pubmed



Sharifian K¹ ; Shoja Z² ; Jalilvand S¹
Source: Virus Genes Published:2024

Abstract

The current study aimed to investigate the sequence variations of HPV 51 and 59 in normal cervical cells and premalignant/malignant lesions of the cervix to know the common variants of HPV 51 and HPV 59 circulating in Iran. To do this, eighty-five samples that were infected by HPV 51 or HPV 59 were investigated using hemi-PCR to amplify the E6 gene followed by sequencing. Our findings indicated that lineages A and B were detected in 80.4% and 19.6% of HPV 51-positive cases, respectively. Among samples infected with HPV 59, 32.2% belonged to lineage A and 67.8% were classified with lineage B. In conclusion, our results showed that lineage A of HPV 51 and lineage B of HPV 59 are more prevalent and distributed in Iran. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.