Comparison of Endoscopic Versus Focused Parathyroidectomy in Surgical Management of Single-Gland Primary Hyperparathyroidism: A Randomized Clinical Trial Publisher Pubmed



Meshkati Yazd SM¹ ; Shahriarirad R^{2, 3} ; Nayebi S⁴ ; Dehghan P⁵ ; Abbasi A⁴ ; Maghsoodloo F¹ ; Hamedani K¹ ; Nasiri S¹
Source: Langenbeck's Archives of Surgery Published:2024

Abstract

Background: Over recent years, various advanced minimally invasive techniques have been developed for parathyroidectomy, and there was a universal acceptance of these less invasive procedures by surgeons. This study is designed to compare overall outcomes between endoscopic versus focused, single gland parathyroidectomy using intraoperative rapid parathyroid hormone (ioPTH) changes under general anesthesia in primary hyperparathyroidism (PHPT) patients. Method: In this randomized clinical trial, 96 patients diagnosed with PHPT were randomly assigned into two groups endoscopic and focused parathyroidectomy. Baseline clinical and demographical data were collected along with perioperative features. The success rate was evaluated based on ioPTH changes. Results: The ioPTH levels after five minutes in the endoscopic group were significantly lower than the focused group (P = 0.005). The success rate for endoscopic and the focused method was 95.3% and 77.1% during the first five minutes (P = 0.013) and 100% in both groups after ten minutes. A decrease in parathyroid hormone levels was significant in each group but not between each other. Postoperative calcium levels were significantly lower in the focused method (P = 0.042). The focused group also had a significantly shorter operation time than the endoscopic group (P < 0.001). Patient satisfaction with cosmetic outcome was significantly higher in the endoscopic group compared to the focused group. Conclusion: The endoscopic technique was superior to the unilateral focused neck exploration parathyroidectomy in the management of single-gland PHPT. Influencing aspects included higher postoperative calcium levels, more rapid success achievement, and satisfactory cosmetic outcomes in the endoscopic group. However, patient selection and accurate adenoma localization are vital in this method. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.