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Targeting Long Noncoding Rnas in Neuroblastoma: Progress and Prospects Publisher Pubmed



Ataei A1 ; Tahsili M2 ; Hayadokht G3 ; Daneshvar M4 ; Mohammadinour S5 ; Soofi A6 ; Masoudi A7 ; Kabiri M8 ; Natami M9
Authors

Source: Chemical Biology and Drug Design Published:2023


Abstract

Neuroblastoma (NB) is the third most prevalent tumor that mostly influences infants and young children. Although different treatments have been developed for the treatment of NB, high-risk patients have been reported to have low survival rates. Currently, long noncoding RNAs (lncRNAs) have shown an attractive potential in cancer research and a party of investigations have been performed to understand mechanisms underlying tumor development through lncRNA dysregulation. Researchers have just newly initiated to exhibit the involvement of lncRNAs in NB pathogenesis. In this review article, we tried to clarify the point we stand with respect to the involvement of lncRNAs in NB. Moreover, implications for the pathologic roles of lncRNAs in the development of NB have been discussed. It seems that some of these lncRNAs have promising potential to be applied as biomarkers for NB prognosis and treatment. © 2023 John Wiley & Sons Ltd.
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