Hynic a Bifunctional Prosthetic Group for the Labelling of Peptides With 99Mtc and 18Fdg Publisher



Khoshbakht S¹ ; Kobarfard F² ; Beiki D³ ; Sabzevari O⁴ ; Amini M⁵ ; Mehrnejad F⁶ ; Tabib K⁷ ; Shahhosseini S^{8, 9}
Source: Journal of Radioanalytical and Nuclear Chemistry Published:2016

Abstract

With regard to high reactivity and chemoselectivity of HYNIC towards carbonyl of acyclic form of 18FDG and its stable complexes with 99mTc, in this study, LIKKPF as the model peptide was conjugated with HYNIC and labelled with 99mTc (RCP >90 %) and 18FDG for the first time. The RCP of >70 % was achieved for labelling with 18FDG, in the presence of glucose (50–250 μg/mL). Our results showed the high potential of HYNIC conjugated peptides for labelling with 99mTc and 18FDG as 18F-fluorinated prosthetic group, to be clinically accepted for the radiolabelling of peptides. © 2015, Akademiai Kiado, Budapest, Hungary.